Mastery Mode

SSRI: SERT blockade. Nausea via 5-HT3, insomnia and sexual dysfunction via 5-HT2, hyponatraemia via SIADH.
SNRI: adds NET blockade. Dose related blood pressure rise.
Mirtazapine: alpha-2 antagonist, 5-HT2 and 5-HT3 blockade, H1 blockade. Sedation, appetite, no nausea, little sexual dysfunction.
Tricyclics: reuptake inhibition plus muscarinic, H1, alpha-1 blockade. Dangerous in overdose through sodium channel blockade.
MAOI: irreversible ones need tyramine restriction. Moclobemide is reversible and selective for MAO-A.
Agomelatine: MT1 and MT2 agonist, 5-HT2C antagonist. Monitor liver function.
Bupropion: noradrenaline and dopamine reuptake inhibition. Lowers seizure threshold.

Teaching, then a question, then a clinical pearl, then an applied matching item. The interleaving is deliberate. Reading alone feels productive and does very little; being asked immediately is what fixes it.

Q-Bank

Exam-style single best answers with an option-by-option breakdown. Every distractor is explained, because knowing why the wrong answer is wrong is what separates a pass from a scrape.

Flashcards

Rate yourself honestly. Hard comes straight back, medium returns later in the session, easy is retired to long-term review. Being generous with yourself here costs you marks in April.

Short Notes

Condensed to the bone, for the week before the examination. Search for anything, or filter by domain.

Paper A lessons

Full written teaching, published as the course runs. Free lessons open to everyone. Members lessons open once you are signed in.